Research in the Musculoskeletal Research Laboratories has historically focused on the biomechanics and healing of musculoskeletal soft tissues, in particular the ligaments of the knee. Over the past five years, the research focus has widened considerably to include hard tissue as well as cardiovascular tissues including the heart, coronary arteries and smaller vessels involved in angiogenesis. Currently, the laboratory researches a number of areas with an annual research budget of over $1 million. A central theme of our approach to research is the use of multidisciplinary techniques. A primary asset of the MRL continues to be the combination of both experimental and computational techniques, especially in the area of biomechanics, to address research questions that would be impossible to investigate using approaches in a single technical discipline.